Posted by crepuscular on April 24, 2002, at 10:50:56
In reply to Re: SSRI's - why they loose their effect..., posted by tex1 on April 24, 2002, at 3:03:48
interesting. i've come to the opposite conclusion.
i see the effect of AD's as not specific to the transmitter system affected, nor the amount present in the synapse, nor even the direction of inhibition (+ serotonin, - serotonin). rather, i see the brain's response to these agents, and the subsequent gene products/neurotrophic factors created as the final common pathway of the effect.
how else might we explain antidepressants that work by *reducing* serotonin? or the myriad of transmitter systems that are all tweakable as potential AD action sites? same goes for ECT.
i'm not a giant fan of using the specificity of modern AD's as explaining depression as "low serotonin" though in some people, this is indeed the case...
poster:crepuscular
thread:103897
URL: http://www.dr-bob.org/babble/20020416/msgs/103989.html