Posted by dennison on April 14, 2002, at 23:47:08
In reply to Re: New Antidepressants in Development?, posted by DP on April 14, 2002, at 23:02:06
Hi - well first obvious thought reflects that for many years serotonin bandwagon was name of game and if drug was not serotonin based then it would lack the hype and thus the popularity. Another idea about norepinephrine reuptake inhibitors, not being on market would be high resistance from current serotonin based drug manufactures as norepinephrine based drugs would be unique and thus consume a portion of the valuable market share. No drug makes it to the market unless it has a target population or a niche otherwise profits simply will never become significant to justify expense of bringing the drug onto the market..............................................................Dopamine drugs, why there's few of them ever even proposed as putative antidepressants-simple ""abuse potential"", though nomifensine in early 80's did hit market and was a dopamine based anti-depressant,unfortunately a few people had bad rxn's, it was a highly effective antidepressant and had great potential to help specific types of depression--:(:( ...................................................................Ok there's a couple quick thoughts I'll think of more in depth ones , lol latter but those I mentioned are valid!!!!!......................................Geez I almost forgot to mention ""amineptine"" survector---an excellent antidepressant dopamine based , but this beauty was indeed removed simply because it had abuse potential, but treating and relieving depression certainly wouldn't be abuse ---would it----but , oh well they removed it from clinical use anyway:(:(. It was used for a time in europe, now it's basically avaliable nowhere, occassionally seen in underground, but who wants to live underground:), bit of humor there. It's a crying shame though amineptine "survector" could have helped an awful lot of people!!!!!!!!!
poster:dennison
thread:103083
URL: http://www.dr-bob.org/babble/20020408/msgs/103094.html