Posted by Elizabeth on April 10, 2002, at 12:35:58
In reply to Re: Benzo Preferences anyone?? » Elizabeth, posted by mike21 on April 8, 2002, at 19:32:12
> Is nordiazepam just another type of benzo with varying effects for various people?
Yes. Librium and Tranxene, as well as Valium (and many benzos that aren't in clinical use), are metabolized to nordiazepam. In fact, Tranxene basically *is* nordiazepam -- it's metabolized in the stomach.
> ...I am thinking that "if it ain't broke, don't fix it," but I am interested in the number of raves about klonopin on this board. Also, it is maybe 10 times(?) more potent than valium, so I'm thinking over the long haul, it would be a better choice- less for my liver to metabolize.
I don't know how much of a difference that makes -- that'd be a good question to ask your doctor. Still, I think it'd be perfectly fine to follow your "if it ain't broke..." reasoning. (Consider that I take 375 mg/day of Effexor and 1200 of Trileptal with no liver problems.)
> This next question probably falls under "YMMV" but would you expect valium or klonopin to have a longer therapeutic half-life?
You mean duration of action? Klonopin. Valium generally doesn't last nearly as long as you'd expect it to based only on its half-life. An elimination half-life is based on the assumption that the concentration is the same everywhere in the body. Klonopin is distributed very differently from Valium and the like, and the result is that it lasts longer. (Other benzos that resemble Klonopin in their volumes of distribution include flunitrazepam (Rohypnol) and nitrazepam (Mogadon).)
-elizabeth
poster:Elizabeth
thread:101944
URL: http://www.dr-bob.org/babble/20020408/msgs/102631.html