Posted by dennison on April 8, 2002, at 22:33:38
In reply to Re: Parnate advice anyone? Please!, posted by SLS on April 8, 2002, at 20:56:44
Hi Agree with SLS parnate has never been shown to be metabolized to methamphetamine . Parnate doesn't undergo cyclopropyl ring opening which would need to occur to form the basic amphetamine backbone. Perhaps you were thinking of l-deprenyl which of course is metabolized to amphetamine. L-deprenyl the selective monoamine oxidase-b specific enzyme blocker is metabolized to approx. equal portions of L-desmethyl-selegiline, L-amphetamine, L-methamphetamine. "Selegiline is simply the brand name of L-deprenyl" --BTW................................................................................................................................................The L-forms of amphetamine and methamphetamine are considerably less potent than the R-forms of course--((( L-levo--- R-dextro , but they do have some amphetamine properties that contribute to L-deprenyl's overall behavioral effects................................................................................................................................................................Ok--Back to parnate - I've taken it for several years , alone and with cylert---It has it's advantages and disadvantages - dietary and drug restrictions - no problem there --the only real problem is the bloodpressure lowerring effect from the parnate- and the sympathetic block, --- for some it's relatively insignificant, for others it's very troublesome. Btw small doses of ritalin and dexedrine as stated by SLS have indeed been used with maoi's, to offset side-effects or boost effectiveness, so that is a valid option, though not all pdoc's are willing to go down that road as pdr has such strong contra-indications of stimulants with maois. Good Luck !!!!!!!!!!!!! :) P.S. BTW one big advantage of parnate was absolutely no cognitive blunting - thinking and concentration were in no way negatively affected, every other anti-depressant I've ever tried interferred with my concentration, some severly so!!!!!!
poster:dennison
thread:102416
URL: http://www.dr-bob.org/babble/20020408/msgs/102469.html