Posted by SLS on April 5, 2002, at 10:13:03
In reply to Re: Kramer - Oophorectomy and PMDD-Tried Lupron? » Elayne, posted by Chris A. on April 5, 2002, at 0:39:46
> We discussed the Lupron option and ruled it out. My gyn felt it would make the bipolar worse.
Hi Chris.
Thanks for the kind words in your previous post. Your gyn's conclusion regarding Lupron is absolutely justified. I know someone with bipolar disorder for whom it wreaked havoc. Lupron is well-known to produce severe depression, including psychotic depression.
Some researchers have been looking at using NATURAL progesterone as a mood-stabilizer for women. I should think that it would work. I emphasize that it be natural because all of the synthesized ones are known to be depressogenic – the important singular exception being drospirenone, which is the progestin component of Yasmin. Progesterone has been shown to exert significant anticonvulsant effects, although it might be through the its active metabolite, 3 alpha, 5 apha-THP , that it accomplishes this (GABAA-benzodiazepine receptor activation). Don’t be too impressed, I looked it up while searching for material to corraborate my not-so-reliable rembering of the mood-stabilizing stuff (which now I can’t find).
For what it’s worth, I think you’re doing the right thing. Of course, I have been know to be wrong on rare occasions. :-)
- Scott
poster:SLS
thread:101606
URL: http://www.dr-bob.org/babble/20020402/msgs/101971.html