Posted by OldSchool on April 2, 2002, at 20:52:22
In reply to That is incorrect Dr. Kramer, posted by Tye on April 2, 2002, at 20:20:07
> > Yeah. Unfortunately, it didn't work all that well. A Phase III clinical trial completed a while ago showed no signifigant difference from placebo.
>
> Dear Dr. Kramer,
>
> Actually the rate of response of the subjects enrolled in the selegiline patch study was approximately 75%. This was amongst a population that was for the most part treatment resistant with HAM-D scores averaging around 30. Unforunately, political agendas impair excellent medications from reaching the United States patient population, as I am sure your aware.
>
> TyeThis was my impression of high dose selegiline. Its an excellent...outstanding antidepressant at doses of 30 mg and above. In fact, there is a whole string about high dose selegiline used as a regular MAOI for depression in the tips and tricks on this website. Many of the Pdocs who posted in the tips here who have used selegiline at higher irreversible MAOI dosages say its a fine AD.
Something isnt right here. Either this MAOI patch doesnt use a high enough dose of selegiline. Or it fails in the delivery somehow. But I am skeptical that high dose selegiline is as good as "placebo" for severe depression.
I agree about the political agendas as well. There isnt enough good research in psychiatry. Mostly its just "another SSRI" type research. Or psychobabble crap.
Old School
poster:OldSchool
thread:101404
URL: http://www.dr-bob.org/babble/20020402/msgs/101571.html