Posted by SLS on April 2, 2002, at 16:21:48
In reply to Dr Kramer: AED cocktails for BPII/NOS., posted by JahL on April 1, 2002, at 22:23:23
> I have read encouraging reports about Lamictal + VPA (which reduced SI when I took it alone) but I am concerned about the obvious interaction.Just a thought, JahL...
If you are a little squirrely about adding Depakote to Lamictal, you may want to try filling that role by adding Neurontin first. In a superficial way, Neurontin and Depakote are similar in that they are both pro-GABAergic. Lamictal is not. This combination has been used quite a bit at the NIMH by Post's group. They claim some good results with BP II. Otherwise, just cut in half the dosage of Lamictal when you add Depakote. 1/2 is usually right on target.
Lamictal: Na+ channel blockade + NMDA antagonism (no increase in GABA activity)Depakote: Na+ channel blockade + increased GABA activity
Neurontin: Increased GABA activity (no Na+ channel blockade)
- Scott
poster:SLS
thread:101386
URL: http://www.dr-bob.org/babble/20020402/msgs/101518.html