Re: What Zyprexa is excellent for - Old School

Posted by Denise528 on April 2, 2002, at 11:53:44

In reply to Re: What Zyprexa is excellent for - Old School » Denise528, posted by SLS on April 2, 2002, at 10:53:29

> > Thanks Scott,
> >
> > Thanks for the explanation, it's clear to me now. However, do SSRIs perform Antagonistic or Agonistic actions or are reuptake inhibitors different?
> >
> > Denise
>
>
> In the most generic sense, an agonist promotes, and an antagonist inhibits, the event being referred to.
>
> I have seen some authors of medical literature refer to a reuptake-inhibitor as an "indirect" agonist of postsynaptic receptors. These drugs do not attach directly to receptors, and are thus not considered to be receptor ligands. That a serotonin reuptake inhibitor drug like Prozac increases the amount of serotonin in the synaptic cleft (the gap between the pre- and post- synaptic neurons), it causes an increase in the rate of stimulation of the attendant serotonin receptors, as long as these receptors are not also antagonized (blocked) by the same drug. The drug therefore is an agonist of serotonergic receptor stimulation. I do not like this usage of the words "agonist" and "antagonist". They are usually reserved for receptor ligands.
>
> LIGAND: An ion, a molecule, or a molecular group that binds to another chemical entity to form a larger complex. (The American Heritage® Dictionary)
>
> DA (dopamine) antagonists: Zyprexa, Risperdal, Haldol, Thorazine - neuroleptic antipsychotics
>
> DA agonists: Mirapex, Parlodel, Permax, Requip... - anti-parkinsons drugs
>
>
> -------------------------------------
>
>
> 5-HT = serotonin
>
> Among other things, Serzone does the following:
>
> 1. inhibits 5-HT reuptake
> 2. antagonizes 5-HT2 receptors
>
> The net effect is that Serzone promotes an increase in the stimulation of 5-HT1 and 5-HT3 receptors, but a decrease in the stimulation of 5-HT2 receptors.
>
> That's enough thinking for today. My brain hurts.
>
> :-)
>
>
> - Scott
Scott,
Thanks for such a concise explanation.
Denise

Thread

zyprexa for atypical depression? KB 3/28/02
...
Re: zyprexa for atypical depression? OldSchool 3/31/02
Re: zyprexa for atypical depression? crepuscular 4/1/02
Re: zyprexa for atypical depression? » OldSchool SLS 4/1/02
Re: Zyprexa *never* for depression! » OldSchool SLS 4/1/02
Re: zyprexa for atypical depression? » SLS SLS 4/1/02
What Zyprexa is excellent for! Tye 4/1/02
Re: What Zyprexa is excellent for! » Tye SLS 4/1/02
Re: What Zyprexa is excellent for - Old School Denise528 4/2/02
Re: zyprexa for atypical depression? Coyote 4/2/02
Re: What Zyprexa is excellent for - Old School » Denise528 SLS 4/2/02
Re: What Zyprexa is excellent for - Old School Denise528 4/2/02
Re: What Zyprexa is excellent for - Old School » Denise528 SLS 4/2/02
Re: What Zyprexa is excellent for - Old School Denise528 4/2/02
Zyprexa progress report KB 4/2/02
Re: Zyprexa progress report » KB ChrisK 4/3/02
antipsychotic drugs Elizabeth 4/4/02
Re: antipsychotic drugs (nice write-up) (nm) » Elizabeth JohnX2 4/4/02
Re: antipsychotic drugs » Elizabeth JohnX2 4/4/02
Re: antipsychotic drugs crepuscular 4/4/02
Re: zyprexa +zoloft Seweryn 6/5/02
xxx for just 70 USD Seweryn 7/29/02
Zyprexa - life saver and small wonder- Corrected totoslim 12/14/02
Re: medication without a prescription » totoslim Dr. Bob 12/14/02
Re: zyprexa for atypical depression? Sarina 12/3/03
Re: zyprexa, *seoquel mode of action » SLS Geoffrey Ruch 4/19/04

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URL: http://www.dr-bob.org/babble/20020402/msgs/101472.html