Posted by Bekka H. on April 1, 2002, at 19:35:15
In reply to dexedrine augmentation of ssri's , posted by dennison on April 1, 2002, at 14:22:44
Yet here's the quandry, many laboratory studies have shown ssri's to negate the psychomotor aspects of psychostimulants. Release of dopamine into nucleus accumbens etc wasn't blunted, nonetheless psychomotor effects were reduced to baseline, no behavior effect was generated. The negation of the psychomotor enhancing effects therefore, was obviously somehow down stream of the dopamine post synaptic receptors --reciprocal diminution by enhanced serotonin functioning of some manner
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Hi Dennison, I was just about to ask Dr. Kramer a similar question, so I'll wait to see his response to yours. The reason I'm writing now is that I wonder whether you have a citation (or two) for the above studies you referred to. I've been on several SSRI plus stimulant combos, and I've experienced what your post describes. In fact, at times, it feels like nearly complete negation of the positive aspects of BOTH drugs. It feels as if they are counteracting each other. If you have references readily available, I'd like to read them. Thanks so much.
Bekka
poster:Bekka H.
thread:101313
URL: http://www.dr-bob.org/babble/20020327/msgs/101354.html