Posted by TSA West on March 25, 2002, at 2:50:29
In reply to Moclobemide/Kava Kava combination?, posted by Will_Hung on March 24, 2002, at 20:24:11
Thank you for posting, Will.
Theoretically, kavalactones may have negative additive effects with inhibitors of MAO type B (moclobemide included). Also, some norepinephrine action may be going on with it. But these actions have yet to be proven with commercial extracts:
(Seitz U. "Monoamine uptake inhibition properties of kava pyrones. Planta Med 1997.")
Significantly, MAOI-type drugs interfere with normal sleep patterns. Kava may be a solution to this problem, because is believed to improve the quality of sleep in humans-- with deep sleep increased and rapid-eye-movement sleep unaffected:
(Kava drug monograph. Denver: Micromedex. Updated 1998 Sept).
If Moclobemide causes anxiety because of stimulant-action or otherwise, you should know that a few small, placebo-controlled, double-blind studies have shown kavalactones to be significantly better than placebo in patients suffering from anxiety of nonpsychotic origin. Importantly, the dosage used for anxiety in these trials was _70 mg_ of a purified kavalactone extract known as WS/1490 _three times daily_:
(Kinzler E. Double blind study of kava with placebo over 4 weeks. Arzneimittelforschung 1991).
I wish you luck with Kava and your journey in emotional wellness...
---------TSA West: Daily Self-Denial in Progress-----------------
poster:TSA West
thread:99946
URL: http://www.dr-bob.org/babble/20020322/msgs/99987.html