Posted by JohnX2 on March 25, 2002, at 2:34:32
What happens if these ADs go too far.
Too much D2 upregulation, D1 downregulation, etc.
Poop out?
Thoughts?John
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8096430&dopt=AbstractLong-term imipramine effects are prevented by NMDA receptor blockade.
De Montis MG, Gambarana C, Meloni D, Taddei I, Tagliamonte A.
Institute of Pharmacology, University of Siena, Italy.
Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cyclase to dopamine stimulation in the limbic system. Moreover, the number of beta-adrenergic receptors and the response of adenylyl cyclase to beta-adrenergic stimulation in the cortex result to be reduced. The present data confirms that imipramine (10 mg/kg twice a day for 3 weeks) produces such effects, and shows that the co-administration of imipramine with MK-801 (administered by a subcutaneously implanted osmotic minipump delivering 0.05 mg/kg/day of the compound) prevented the occurrence of both the behavioral supersensitivity to quinpirole, and the decrease of dopamine D1 and beta-adrenergic receptor function.
PMID: 8096430 [PubMed - indexed for MEDLINE]
poster:JohnX2
thread:99985
URL: http://www.dr-bob.org/babble/20020322/msgs/99985.html