Posted by fachad on March 24, 2002, at 4:09:05
In reply to ANYONE: Y R TCA's but not SSRI's anticholinergic?, posted by Janelle on March 23, 2002, at 21:11:00
That's EXACTLY right - you're getting it, and it's only been a few weeks. Think where you'll be after you've been at this for a while!
What you just wrote: "Based on this, my conclusion is that SSRIs and ADs such as Effexor which works on both Serotonin and Norepinephrine are SPECIFICALLY targeted to these neurotransmitters, whereas TCAs act on these neuros plus OTHER ones and it is their action on OTHER ones which may cause the anticholinergic side effects?"
This is a key thing. SSRI are SPECIFIC Serotonin Reuptake Inhibitors. They are clean in that they do what they are supposed to do, and nothing else. Effexor is an SSNIR; it is SPECIFIC, but it blocks both NE and 5HT uptake.The whole quest for new drugs is to find ones that will affect the target receptors and have the desired actions without affecting other receptors and causing side effects.
> I'm copying/pasting something from the link provided by Fachad (great stuff there, btw!) and would appreciate it if someone could verify if I'm understanding it properly:
>
> for TCA's it says "Serotonin and norepinephrine reuptake inhibition plus effects on multiple receptors and fast sodium channels (e.g., amitriptyline, imipramine)"
>
> Based on this, my conclusion is that SSRI's and AD's such as Effexor which works on both Serotonin and Norepinephrine are SPECIFICALLY targeted to these neurotransmitters, whereas TCA's act on these neuros plus OTHER ones and it is their action on OTHER ones which may cause the anticholinergic side effects?
poster:fachad
thread:99599
URL: http://www.dr-bob.org/babble/20020322/msgs/99809.html