Posted by cisco on March 22, 2002, at 18:59:13
In reply to opiate/opioid therapy, posted by A0102 on March 21, 2002, at 7:59:54
Adam:
Hell yes, Opioids have a quick, and very effective, anti-depressant effect.
Unfortunately, due to the rapid build up of tolerance, you will find yourself in a geometric progression of dose increases.
In my opinion, you will be better off taking 'Long-acting' Opioids (Dolophine, Buprenorphine, LAAM) to avoid the mood swings inherent with the 'Short-acting' Opioids (Morphine, Oxycodone, Hydrocodone).
Buprenorphine is very good at saturating the brains Opioid receptors. Mixed agonist/antagonist at the Mu, it is a potent Kappa antagonist.
Dolophine (methadone) is a very simple, open chain molecule, opioid. It is a potent Mu agonist, that is prized for its slow onset, and long duration. These same qualities are said to make withdrawals difficult. It is also the most controlled drug in the world. Which can make it a PITA.
Anyway, I say go for it. Read up on candidate meds, make a choice. Feel good!!
Cisco
poster:cisco
thread:99196
URL: http://www.dr-bob.org/babble/20020322/msgs/99518.html