Posted by JohnX2 on March 26, 2002, at 20:30:13
In reply to Re: Aripiprazole and d2 upregulation, posted by SLS on March 26, 2002, at 19:49:46
Hi Scott,I found this one:
http://www.dr-bob.org/babble/20020322/msgs/99976.html
I didn't dig too far though.
I really was just looking for some background data on TD and also possibly correlations to the limbic system.I think Aripiprazole looks quite exciting. Any news on its release date?
PS. I am done with APs until Aripiprazole or a means to safegaurd against TD (which i believe there is from my posting).
I think my mild dystonia was brought on by my severe manic episodes in January and the very heavy Zyprexa dosing.
Regards.
John
> > Aripiprazole, a novel antipsychotic drug, inhibits quinpirole-evoked GTPase activity but does not up-regulate dopamine D2 receptor following repeated treatment in the rat striatum.
>
>
> Hi John.
>
> This looks encouraging.
>
> Can you find anything that makes a similar comparison to olanzapine or ziprasidone? It might help to elucidate whether or not the reduced magnitude of DA D2 receptor upregulation can be assigned to those properties of aripiprazole that Stephen Stahl characterizes as being of a DSS (dopamine system stabilizer). Aripiprazole has been described by others as being a partial DA receptor agonist.
>
>
> - Scott
poster:JohnX2
thread:99979
URL: http://www.dr-bob.org/babble/20020322/msgs/100399.html