Posted by Hal on March 18, 2002, at 21:10:44
In reply to Re: Why do people prefer ssri's over Wellbutrin?, posted by OldSchool on March 18, 2002, at 20:14:11
Hey Everyone,
My take on poop out is it has nothing to do with the medication. The med, whether an SSRI or even an antibiotic does not change over time, the drug molecule is the same. What does change is the metabolism of the medication or the disease itself. If your body starts to metabolize the med quicker, just increase the dose and the efficacy will return. If the disease changes, that is the bacteria mutates or the depression changes, the medication may become less effective and increasing the dose will do nothing. You need a new medication.
There is no reason to think depression is different from other diseases, it probably changes and evolves over time. I think it is a minority of patients which find a the same med is effective over their entire life. Most need to shuffle meds occassional throughout their life. Be that as it may, my mother has been on the same med for 25 years, yet my father has needed to periodically change meds when the depression breaks through on particular medication.
This is pure theory and conjecture on my part!
Hal
poster:Hal
thread:98340
URL: http://www.dr-bob.org/babble/20020318/msgs/98681.html