Posted by JohnX2 on March 18, 2002, at 17:19:27
In reply to JOHNX2 - re weight gain » JohnX2, posted by Janelle on March 17, 2002, at 14:23:10
> John,
>
> Here I am again, back to pick your brain! Okay, you said that a lot of these medicines block the "alpha-1" noradrenaline receptor as well as the histamine receptor (I follow that!) and that this "alpha-1" receptor affects your metabolism, and that blockade of alpha-1 receptors or antihistamines can induce drowsiness.
>
> You also said that you gained quite a bit of weight on Zyprexa and Serzone (both alpha-1 antagonists) so my question is: does the BLOCKADE of alpha-1 receptor and the metabolic changes this causes then result in weight gain?
>
> I have been on Zyprexa for about a year - when I started on it my appetite became immense but I did NOT give into it (that was difficult but I managed). My depression had *helped* me in one way - I had lost my appetite and shed about 30 pounds which I really needed to lose. So when Zyprexa started giving me the munchies big time I just drank water or ignored them. After awhile the Zyprexa stopped increasing my appetite.
>
> I'm surprised that you never gained weight on Remeron - just about everyone I read about who's on that one gains weighton it.Maybe it is not a good idea to make too many generalizations. Everyone who takes medicines will find one where they are an exception to the rule and escapes the statistical bad side effect. Don't shy away from testing out medicines with bad reps if you have beaten down the better paths with failures and are grasping at staws (just my opinion). Of course, you would like to hear a few success stories on that medicine (like Serzone). This is just my opinion.
>
> So, what's the story with weight gain - is it the blocking of the alpha-1 receptor that causes it? Thanks as always.My doctor claims it is increased appetite and not metabolic slow down. This would seem to correlate with my Topamax add on which killed my appetite and stopped the weight gain of Zyprexa and Serzone. I'm not convinced there can't be a metabolic link also.
Thanks for the insightful questions.
regards
John
poster:JohnX2
thread:98391
URL: http://www.dr-bob.org/babble/20020318/msgs/98627.html