Posted by OldSchool on March 13, 2002, at 13:21:01
In reply to Re: CRF Antagonists, posted by Denise528 on March 13, 2002, at 13:01:48
> Thanks for the response, I suppose I'm just clutching at straws.
> What I really want to know is why SSRIs and tricyclics are no longer working when they used to work so well when I came off them two years ago they were still working so hadn't pooped out at all. Surely there must be a scientific reason for this, am I just not creating any Serotonin in the first place, I really don't understand.
>
> The depression is the same as it was before so I still think it is serotonin related. The only reason I knew back then that I was suffering from depression and not some physical disease was that an AD cleared up all my symptoms. Now they don't, does that mean I'm not depressed?
>
>
> Any ideas?
>
> DeniseThere is some info on this site regarding "SSRI poopout." Its in the tips and tricks section. Basically, the most common hypothesis as to why ADs poop out over the long haul is dopamine depletion. Many ADs, particularly the serotonergic ones, dampen the dopamine system when taken long term.
Im building a website myself and will have information on this subject at my site.
Old School
poster:OldSchool
thread:97638
URL: http://www.dr-bob.org/babble/20020313/msgs/97804.html