Posted by BarbaraCat on March 5, 2002, at 13:18:38
In reply to Inositol question for Cam W., posted by Blue Cheer 1 on March 5, 2002, at 10:18:10
Please note that the Jarrow Formulas form I use is myo-inositol in powdered form. The label reads 'this product contains pharmaceutical grade crystalline inositol. Contains no other substances'. There are other forms, inositol-hexaphosphate, IP6, etc., useful for other things but not mood disorders. Another form, epi-inositol has been the form touted as primary for affective disorders (practically impossible to locate and purchase, however). Here is a blurb reporting this:
Epi-Inositol and Inositol Depletion: Two New Treatment Approaches in Affective Disorder
by
Bersudsky Y, Einat H, Stahl Z, Belmaker RH
Beer-Sheba Mental Health Center,
PO Box 4600, Beer-Sheba, Israel.
Curr Psychiatry Rep 1999 Dec;1(2):141-147ABSTRACT
Inositol is a simple polyol precursor in a second messenger system important in brain myo-insitol, the natural isomer, which has been found to be therapeutically effective in depression, panic disorder, and obsessive-compulsive disorder in double-blind controlled trials. Recently, epi-inositol, an unnatural stereoisomer of myo-inositol, was found to have effects similar to those of myo-inositol to reverse lithium-pilocarpine seizures. We measured the behavior of rats in an elevated plus maze model of anxiety after chronic treatment of 11 daily intraperitoneal injections of epi-inositol, myo-inositol, or control solution. Epi-inositol reduced anxiety levels of rats compared with controls, and its effect was stronger than that of myo-inositol. Lithium has been hypothesized to alleviate mania by reducing brain inositol levels. Inositol in brain derives from the second messenger cycle, from new synthesis, or from diet via transport across the blood brain barrier. Because the first two are inhibited by lithium, we propose that an inositol-free diet will augment lithium action in mania by enhancing restriction of inositol."This last statement is pretty confusing - so is myo-inositol beneficial or detrimental for bipolar disorders? - Barbara
If you do a > Hi Cam - Tomorrow, as part of the STEP-BD study Randomized Care Pathway, I'll be randomized to either Risperdal (which I can't tolerate) or Inositol 12 g/day. Given that I'm randomized to Inositol and respond to it, and want to continue it following the study (even if I get Risperdal, I want to try Inositol), I'm trying to determine which product is closest to the one used in a previous study published by Dr. Chengappa in _Bipolar Disorders_; March, 2000. Here's the link to the firm where he obtained it: http://www.spectrumchemical.com - if you enter I1004 in the search box, it brings you to it. (500 grams for $74.80)
> Since they won't sell to individuals (though there's a toll-free no. for pharmacists), someone gave me two names of chemical firms that sell to individuals. They are: http://www.voightglobal.com (click on "Nutraceuticals" and scroll down to "inositol") - 500 g = $85.00
> and: http://www.lktlabs.com (click on "catalog", then on left "G-L - 500 grams = $77.50).
> Now, I read BarbaraCat's post about Jarrow Formula and it's a fantastic price. (About 25% of the cost of the other products.) My question is: Is there a difference in the quality among the inositol sold by the three firms I listed and the inositol made by Jarrow Formulas? I'm wondering how Jarrow could sell it so much cheaper, but if all the formulations are equivalent, then of course I'd purchase it from Jarrow.
>
> Thanks for any help you can provide.
>
> Blue
poster:BarbaraCat
thread:96166
URL: http://www.dr-bob.org/babble/20020301/msgs/96519.html