Posted by JohnX2 on February 26, 2002, at 20:51:24
In reply to wellbutrin vs. remeron » JohnX2, posted by mike21 on February 26, 2002, at 20:08:01
Mike,Your pdoc prescribed both?
While its hard to predict precisely how medicine
would react in concert in the brain, logic would dictate
that you would want them to work synergistically to
get an additive effect.
As such, I have always felt that a Remeron/Wellbutrin
type combo would have "interference". But there no real clinical
data to back it up. You don't really hear of too many
people trying that combo. I'm aware of a number of
noradrenergic medicines that increase firing in the locus
coeruleus and others that inhibit firing, there projections
from that nucleus is where a lot of the anti-depressant mechanisms
occur. I would see a "conflict of interest" if you combined to
medicines trying to do the opposite thing. Just my opinion
I could be wrong, but you came to the same independant conclusion.Good luck with your medicines.
Frankly I think the Remeron may make the Wellbutrin
quite anxious feeling. I guess Im thinking the Wellbutrin
may enhance the Remerons effect, but it would kill the
Wellbutrins mode of action. (Id explain but Im tired).Regards,
John
> >
> > In regards to Wellbutrin, the medicine long term inhibits
> > firing in an area of the brain called the "locus coeruleus".
> > This is a central noradrenergic nucleus that is very sensitize
> > to stress. Wellbutrin has metabolites that are potent norepinephirine
> > reuptake inhibitors that long term desensitize the alpha-2 feedback
> > receptors in this area of the brain which causes the firing rate to
> > slow down. This causes a net increases in norephinephrine in the synapse
> > with a slower firing rate. The slower firing rate gives reduced anxiety.
> > But it takes time for the alpha-2 feedback receptor to be downregulated.
> .
> .
> .
> > You can really increase the power of Jumex by taking Remeron,
> > but you are playing with fire and will be really anxious.
> > The Remeron antagonizes the alpha-2 feedback receptor and I think will
> > increase the tyrosine hydroxylase enzyme. This
>
>
> It seems that remeron would actually block wellbutrin from performing its main action: desensitizing the alpha-2 feedback receptor. I was recently prescribed both, but am now questioning the point of using both at once. I guess it could be that the wellbutrin is somehow meant to augment remeron and some of its side-effects. What are your thoughts?
>
> Mike
poster:JohnX2
thread:95046
URL: http://www.dr-bob.org/babble/20020222/msgs/95640.html