Posted by Ray on February 25, 2002, at 0:27:02
In reply to Re: Why isnt Moclobemide available in the USA? » OldSchool, posted by JohnX2 on February 23, 2002, at 23:20:40
The North American studies of moclobomide for Social Phobia showed no statistical benefit. Brofaromine did show moderate benefit though, but that one looks gone for good.
For depression, I'm not sure how well moclobomide works. I tried it and I did not experience any adverse effects except prosexual (yes!), and also I was a bit sweaty and nervous. Trial was too short for only a week and dose normally goes real high for SP whereas I was medium. But at side effect profile seemed consistent with what I read. ie; slightly prosexual, slight anxiety and/or insomnia.
For such a well tolerated antidepressant I would think it would generally be far more popular everywhere everywhere it is available than it is, and that it would be in USA also; if it were highly effective for various types of depression. But I don't know. Just my thoughts...
Ray
> I talked to a nurse at Roche Pharmaceuticals
> to inquire about obtaining moclobemide and asked
> why it wasn't made available in the US. She seemed
> to indicate that it purely was for marketing reasons.
> It seemed to be more because of the stigma associated
> with MAO inhibitors and the tyramine effect depite the RIMA
> mode of action in Manerix. The huge cost to get get moclobemide
> approved and marketed in the US and given the current market conditions
> and misconceptions regarding the dangers of such medications
> did not warrant a good invest from a risk/reward stand point.
> Sad.
>
> -John
>
poster:Ray
thread:94769
URL: http://www.dr-bob.org/babble/20020222/msgs/95398.html