Posted by Jaynee on February 22, 2002, at 17:53:31
Hi I have just started to take passion flower drops for anxiety. I am also on Celexa. Has anyone tried this. Also has anyone else added to chromium to their anti-depressants, and what were the results.
Here are the articles that got me interested in both of this alternatives.
Passionflower in the treatment of generalized anxiety: a pilot double-blind
randomized controlled trial with oxazepam.Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M.
Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, South Kargar Avenue,
Tehran, Iran. s.akhond@neda.netOBJECTIVE: Passionflower (Passiflora incarnata) is a folk remedy for anxiety. A double-blind
randomized trial compared the efficacy of Passiflora incarnata extract with oxazepam in the
treatment of generalized anxiety disorder. METHODS: The study was performed on 36
out-patients diagnosed with GAD using DSM IV criteria. Patients were allocated in a random
fashion: 18 to the Passiflora extract 45 drops/day plus placebo tablet group, and 18 to oxazepam
30 mg/day plus placebo drops for a 4-week trial. RESULTS: Passiflora extract and oxazepam
were effective in the treatment of generalized anxiety disorder. No significant difference was
observed between the two protocols at the end of trial. Oxazepam showed a rapid onset of
action. On the other hand, significantly more problems relating to impairment of job performance
were encountered with subjects on oxazepam. CONCLUSION: The results suggest that
Passiflora extract is an effective drug for the management of generalized anxiety disorder, and the
low incidence of impairment of job performance with Passiflora extract compared to oxazepam is
an advantage. A large-scale trial is justified.Publication Types:
Clinical Trial
Randomized Controlled TrialPMID: 11679026 [PubMed - indexed for MEDLINE]
Int J Neuropsychopharmacol 2000 Dec;3(4):311-314
Related Articles, Books, LinkOut
Chromium treatment of depression.McLeod MN, Golden RN.
Eight patients with refractory mood disorders received chromium supplements and described
dramatic improvements in their symptoms and functioning. In several instances, single-blind trials
confirmed specificity of response to chromium. Side-effects were rare and mild, and most
commonly included enhanced dreaming and mild psychomotor activation. To our knowledge, this
is the first case series describing the response to chromium monotherapy. The putative
antidepressant effects of chromium could be accounted for by enhancement of insulin utilization
and related increases in tryptophan availability in the central nervous system, and/or by
chromium's effects on norepinephrine release.PMID: 11343609 [PubMed - as supplied by publi
poster:Jaynee
thread:95148
URL: http://www.dr-bob.org/babble/20020222/msgs/95148.html