Posted by Rick on February 18, 2002, at 22:26:45
In reply to Is Celexa + Buspar + Serzone ok?, posted by Kristen on February 16, 2002, at 4:41:37
In addition to the cautions already passed along to you, if you look at the Precautions section of monograph for Serzone (e.g. at www.rxlist.com), you'll see that there is a BIG metabolic interaction between Serzone (nefazodone) and BuSpar (buspirone). At typical Serzone doses, Serzone can increase the amount of BuSpar in the blood by up to 20 times!
Now, magnitude of increase in plasma level doesn't necessarily directly correlate to magnitude of increase in BuSpar effects (or side effects). Moreover, you're talking about taking far less than a "typical" dose of Serzone, and spreading out the dosing of the different meds.
Nonetheless, please be careful here! Probably best to talk to your doctor before making ANY dosage adjustments (not that all docs are necessarily attuned to all the interactions), but at the very least, first check for possible interactions on the web, or in a book.
Rick
> Hi, I have been happy with Celexa 40 mg. so far for depression and panic....now i start to feel apaty and so on.
>
> So it think i will reduce Celexa to 20 mg, and add some Buspar to boost up a little bit,
>
> Because of sleep problems I also wonders about Serzone.
>
> Let say I took:
>
> - 20 mg Celexa in morning
> - 15-30 Buspar day
> - 25-75 Serzone at night
>
> Any comments please...and what would be the result for my brain receptors?
>
> Kristen
poster:Rick
thread:94385
URL: http://www.dr-bob.org/babble/20020215/msgs/94567.html