Posted by JohnX2 on February 18, 2002, at 15:16:15
In reply to Re: DA downregulation Postsynaptic Hypothesis. » JohnX2, posted by dazednconfused on February 18, 2002, at 7:17:10
I need to think about your idea.
I haven't tried (ami)sulpride, but would like
to.Regards,
John> Hi John,
> your theory is quite interesting!
> If i had understand well you mean that:
> more dopamine in the synaptic zone=more post-syn aptic receptors;
> more post-synaptic receptors=more pre-synaptic receptors;
> more pre-synaptic receptors=more reuptake of dopamine in the intercell zone;
> more reuptake of dopamine=less dopamine available in your brain.
> The circle is closed and it seems don't to have an end!
> I could be agree with you, but let me suppose that we could break this circle:
> we know that 100 mg of amisulpride, L-sulpiride or 400 mg of sulpiride, totally saturate the pre-synaptic receptor, making them completely off.
> So we could stop the reuptake of dopamine at all!
> However, if it shouldn't works, we could anyway increase the amount of dopaminergic med till we could block all pre-synaptic recetors.
> You know you could increase amisulpride up to 400 mg or more without interact with post-synaptic cell, and so, acting only at pre-synaptic receptors level.
> What's your opinion about? What could you suppose to do in this case?
> Bye
poster:JohnX2
thread:94402
URL: http://www.dr-bob.org/babble/20020215/msgs/94513.html