Provigil induces metabolism of Klonopin :(

Posted by 3 Beer Effect on February 8, 2002, at 17:08:36

I have done some research & have unfortunately found out some dissapointing news:
Provigil (Modafinil, Alertec), it turns out induces metabolism of drugs such as Klonopin (clonazepam) that are metabolized through the Cytochrome-P450 CYP3A4 liver enzymes. According to the official Klonopin prescribing information inducers of this enzyme such as Provigil, Dilantin, Phenobarbital, & Tegretol result in faster Klonopin metabolism, & an approximately 30% decrease in plasma Klonopin levels (both of which reduce the effectiveness of Klonopin for social phobia).

See PRECAUTIONS (drug interactions) for Provigil at--
http://www.provigil.com/pi.htm
Also see PRECAUTIONS (Drug interactions) at the revised (1999) official Roche Laboratories Klonopin Presribing information--
http://www.rocheusa.com/products/klonopin/pi.html

Thread

Provigil induces metabolism of Klonopin :( 3 Beer Effect 2/8/02
Thanks, I may be taking both of those soon.... (nm) » 3 Beer Effect Ritch 2/9/02
Why would you take if both don't work well mixed?? (nm) » Ritch Jason911 2/9/02
Provig DOESN'T Induce Klon/And if Did, No Big Deal » 3 Beer Effect Rick 2/9/02
Re: Why would you take if both don't work well mixed?? » Jason911 Ritch 2/9/02
An Excellent Reply and Reasoning » Rick IsoM 2/9/02
Re: Provigil induces metabolism of Klonopin :( » 3 Beer Effect Mr. Scott 2/9/02
Thanks (nm) Rick 2/10/02
Re: Thanks, IsoM, that is (nm) Rick 2/10/02
Good News:Three beers ups the effect of Klonopin:) » 3 Beer Effect manowar 2/11/02
Re: Provig DOESN'T Induce Klon/And if Did, No Big Deal » Rick manowar 2/11/02
Re: Provig DOESN'T Induce Klon/And if Did, No Big Deal » manowar Rick 2/12/02
Re: Provig DOESN'T Induce Klon/And if Did, No Big Deal » Rick Lorraine 2/13/02
Re: Provig DOESN'T Induce Klon/And if Did, No Big Deal » Rick manowar 2/13/02
Re: Provig DOESN'T Induce Klon/And if Did, No Big Deal » Lorraine Rick 2/13/02
Re: Thanks re thoughts on Blood pressure (nm) » Rick Lorraine 2/13/02

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