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Only alcohol, benzos, selective for GABA-A???

Posted by 3 Beer Effect on February 2, 2002, at 16:56:08

In reply to Re: anticonvulsants for anxiety » 3 Beer Effect, posted by Elizabeth on February 2, 2002, at 14:24:28

I was looking at the gabitril.com website and it appears that the proven anxiolytic/social phobia drugs like alcohol, benzodiazepines, & the barbituates only affect GABA-A.
http://www.gabitril.com/physicians/gaba/default.asp

The Role of GABA in CNS:
GABA binds to 3 principal receptors, each of which is involved in different physiologic functions:

GABA-A receptors-- mediate fast inhibitory synaptic transmissions; they regulate neuronal excitability (eg, seizure threshold) and rapid changes in mood (eg, anxiety, panic, and response to stress); they are targets of benzodiazepines, barbiturates, and ethanol.

GABA-B receptors mediate slow inhibitory potentials; they appear to be important in memory, mood (depression), and pain.

GABA-C receptors –– their physiologic role has not yet been described.


Since Gabitril is not selective for GABA-A, then would Gabitril cause "dumb drug" effects on memory?

Is there a selective GABA-A agonist besides alcohol, benzos, or barbituatues?

Also, I can't find the "MAOI of GABA" - Sabril (vigabatrine) in the 2002 Nurses Drug Guide or PDR. Is Sabril available in the United States yet? Is Sabril selective for GABA-A?


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