Posted by 3 Beer Effect on February 2, 2002, at 16:56:08
In reply to Re: anticonvulsants for anxiety » 3 Beer Effect, posted by Elizabeth on February 2, 2002, at 14:24:28
I was looking at the gabitril.com website and it appears that the proven anxiolytic/social phobia drugs like alcohol, benzodiazepines, & the barbituates only affect GABA-A.
http://www.gabitril.com/physicians/gaba/default.aspThe Role of GABA in CNS:
GABA binds to 3 principal receptors, each of which is involved in different physiologic functions:GABA-A receptors-- mediate fast inhibitory synaptic transmissions; they regulate neuronal excitability (eg, seizure threshold) and rapid changes in mood (eg, anxiety, panic, and response to stress); they are targets of benzodiazepines, barbiturates, and ethanol.
GABA-B receptors mediate slow inhibitory potentials; they appear to be important in memory, mood (depression), and pain.
GABA-C receptors –– their physiologic role has not yet been described.
Since Gabitril is not selective for GABA-A, then would Gabitril cause "dumb drug" effects on memory?Is there a selective GABA-A agonist besides alcohol, benzos, or barbituatues?
Also, I can't find the "MAOI of GABA" - Sabril (vigabatrine) in the 2002 Nurses Drug Guide or PDR. Is Sabril available in the United States yet? Is Sabril selective for GABA-A?
poster:3 Beer Effect
thread:92589
URL: http://www.dr-bob.org/babble/20020131/msgs/92642.html