Posted by Ritch on January 28, 2002, at 23:27:32
In reply to Re: ADs, RLS, and akathisia--Help (Elizabeth,Cam,TSA)?, posted by Noa on January 28, 2002, at 17:37:26
> I am interested in this line of questions too. Not just for the akithisia effects but other effects of serotonin, like tight jaw muscles, bladder problems, etc. Do you know if this serotonergic-dopamine antagonism process affects any of these issues?
>
> Should I be looking at dopamine agonists?
>
> What about wellbutrin--how does it rate in this regard?
>
> Thanks.
Hi Noa,All I have found out (with BP and ADHD, etc.) is that receptor *specific* meds don't help me very much. DA agonists (pergolide and pramipexole) both just made me nauseous, sleepy, and weird. DA antagonists (thioridazine, atypical AP's) caused dystonia, depression, and EPS, NE antagonists (Remeron, Buspar) caused hostility. 5-HT2x antagonists (Serzone, Remeron) just made me confused-although my IBS was better and I had no heartburn. It has just has been easier for me to use monoamine reuptake inhibitors and carefully adjust the dosage. I liked Zoloft (because of the dual 5-HT and DA reuptake inhibition), but it is too lopsided and blocks the serotonin transporters too excessively. Also, Zoloft "gets into your motor circuits" a lot and does cause a lot of jaw-clenching and teeth grinding and more. I would like to get away from SSri's (for GI upset reasons, esp.), but just can't seem to. Maybe there will be some new stuff soon that won't cause all of these problems-"a tolerable SSRI??".
Mitch
poster:Ritch
thread:91594
URL: http://www.dr-bob.org/babble/20020124/msgs/91970.html