Posted by MB on January 25, 2002, at 15:58:45
In reply to Re: LEVODOPA ? - Interesting !!!, posted by OldSchool on January 25, 2002, at 14:38:01
> I dont agree levodopa has ANY uses in borderline personality disorder, nor any mood or anxiety disorder. Levodopa is a very potent dopamine agonist used for parkinsons and some of the other movement disorders. Its use should be kept to those neurological disorders. Levodopa is more likely to worsen many psychiatric conditions.
>
> If you want to try a direct dopamine agonist try Mirapex, bromocriptine, Amantadine. Or just take stimulants like Ritalin or dexedrine. MAOIs are also potently dopaminergic and indicated for borderline personality disorder.
>
> Leave the levodopa to the people with parkinsons and similar movement disorders. Its not a drug generally taken for psychiatric disorders.
>
> Old School
Is this a fact because l-DOPA targets dopamine receptors in different parts of the the brain than the receprors that Mirapex, bromocriptine and Amantadine target? Is it less of a matter of increasing dopamine, and more of an issue of *where* you increase the dopamine? This has always interested me. For example: I have restless leg syndrome which implies too little dopamine in parts of the brain (I don't know which parts), but I also have tics (which implies too much dopamine in other parts of the brain). If I take a neuroleptic, it helps the tics, but makes the RLS worse. If I take a general dopamine agonist, the RLS goes away, but the tics get worse.
The only drugs that helps both the tics and the RLS are the opiates. They take away the tics and they take away the RLS. They must decrease dopaminergic activity in the brain areas responsible for tics while increasing dopaminergic activity in the parts of the brain responsible for the horrible, restless akathisia.It's all too complicated for me. Are there any geniuses that can help? Maybe Cam? Maybe Elizabeth? Maybe TSA-West?
MB
Sheesh.
MB
poster:MB
thread:91509
URL: http://www.dr-bob.org/babble/20020124/msgs/91582.html