Posted by Ray on January 25, 2002, at 14:50:05
In reply to Provigil/modafinil raising blood pressure????, posted by Rick on January 24, 2002, at 21:15:19
Hi Rick
(my name says Ray is the old KregPark could not stand that name anymore!)
Actually I believe I have similar effect to you with BP.
> Until recently, I only took Provigil soley in combo with Serzone and Klonopin. And my blood pressure was fine...if anything, it dropped a bit. That didn't surprise me, because one advantage of Provigil over traditional stims was supposed to be that it didn't raise BP or heart rate.
In my opinion that is mostly due to Serzone and the hypotension it usually causes. Serzone is a spin off of the older trazodone which is so dizzying it is often intolerable.> That combo is fantastic for my social phobia, but I've been going without Serzone for awhile to see if I can ditch the annoying memory lapses. (I know Klonopin can be amnesic, but I'm on a low dose and had little in the way of memory problems when I was taking Klonopin alone.)
>
> While I've had only modest deterioration in teatment effectiveness, I've been surprised to find that without the Serzone, Provigil clearly raises my BP and heart rate, and also results in much more variation than before. Whereas I'd have a typical 105-120/65-80 in late afternoon, it now routinely gets as high as 150/100. And this is at a relatively low 100 mg. of Provigil. When I've tried 200 mg, which again never affected my BP while I was also taking Serzone, I've gone as high as 160/105.
>
> First-thing-in-the-morning readings are still pretty good. And I know that a person's BP typically rises until about 2 pm, but mine just keeps rising into the evening, and it's too much of a rise.
Traditional stimulants may be hypotensive or hypertensive. Also the up/down effect is signficant so BP may bounce high/low/high/low etc. Provigil does appear to be selective serotonin agonist, and (won't repeat history) - debatably selective dopamine and/or ne boosting also.
I'm not certain but I think serotonin syndrome also leads to high blood pressure.
>
> Any ideas or similar experiences? I'd surmise my reaction probably isn't typical; my BP tends to be very med sensitive in both directions (although Klonopin has no effect). Maybe it's just that the Serzone was lowering it a lot, offsetting a Provigil-induced rise...i.e., maybe I would be hypotensive on Klonopin and Serzone alone. Or was some sort of interaction involved? (Serzone's a powerful inhibitor of liver enzyme CYP3A4, which Provigil uses for clearance, but I don't see how that could attenuate Provigil's BP effect.)
Serzone known to interact negatively with a number of mood stabilzers, Prozac, probably others.As you know I add Provigil to Nardil 60 + Klonopin 2.5
Not long after adding Provigil a year ago, I tried dropping Nardil. Was more stimulating without Nardil. Quite effective I think but hair loss immediately. Was a bit agitated too, and as usual did not have time to give trial due to "back to work".I wonder how Klonopin effects Provigil? Perhaps no Klonopin would render Provigil *less* stimulating...
Oh well better get off computer!!
poster:Ray
thread:91475
URL: http://www.dr-bob.org/babble/20020124/msgs/91572.html