Posted by janejj on January 25, 2002, at 11:12:47
In reply to Social Phobia: Fish Oil/Omega3 (EPA)????, posted by Rick on January 24, 2002, at 22:21:00
> I dug this up for a different thread, but was intrigued by the Social Phobia apsect and thought it deserved its own thread (key sentence in CAPS).
>
> Int J Clin Pract 2001 Oct;55(8):560-3
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> Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover.
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> Puri BK, Counsell SJ, Hamilton G, Richardson AJ, Horrobin DF.
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> MRI Unit, Imperial College School of Medicine, Hammersmith Hospital, London, W12 0HS, UK.
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> The n-3 essential fatty acid eicosapentaenoic acid (EPA) was added to the conventional antidepressant treatment of a treatment-resistant severely depressed and suicidal male patient with a seven-year history of unremitting depressive symptoms. The niacin skin flush test and cerebral magnetic resonance scanning were carried out at baseline and nine months later. The addition of ethyl-EPA led to a dramatic and sustained clinical improvement in all the symptoms of depression, including a cessation of previously unremitting severe suicidal ideation, within one month. SYMPTOMS OF SOCIAL PHOBIA ALSO IMPROVED DRAMATICALLY. During the nine-month period the volumetric niacin response increased by 30%, the relative concentration of cerebral phosphomonesters increased by 53%, and the ratio of cerebral phosphomonesters to phosphodiesters increased by 79%, indicating reduced neuronal phospholipid turnover. Registered difference images showed that the EPA treatment was accompanied by structural brain changes including, in particular, a reduction in the lateral ventricular volume.
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> PMID: 11695079 [PubMed - indexed for MEDLINE]
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> Rick
poster:janejj
thread:91488
URL: http://www.dr-bob.org/babble/20020124/msgs/91546.html