Posted by TSA West on January 22, 2002, at 23:15:23
In reply to Re: Can somebody explain why they stop working. » Denise528, posted by MB on January 22, 2002, at 15:16:56
One possible answer is dopamine depletion over time with SSRIs: http://www.dr-bob.org/tips/split/Patients-who-lose-response.html
Another answer is that peoples' metabolisms change over time such that a drug gets metabolized too fast, and the legal limits prohibit a doctor from prescribing more medication than the Physicians' Desk Reference allows.
I don't think one can prove this happens as much with tricyclic antidepressants.
Be well and prosper,
TSA West, founder: William Booth ++++
poster:TSA West
thread:91095
URL: http://www.dr-bob.org/babble/20020116/msgs/91162.html