Posted by Anna Laura on January 18, 2002, at 1:37:33
In reply to 1 week » Anna Laura, posted by TSA West on January 17, 2002, at 23:40:36
> -----------------TSA West------------------ :)
>
> I'd give it one week to start being effective again at the 300 mg dose. Dose-response in Effexor is linear-- higher doses mean better efficacy in depression, anxiety, and anhedonia.
>
> The antipsychotic in the Parnate could only help, not hurt: (http://www.dr-bob.org/tips/split/Antidep-effects-of-antipsy.html); Parnate is effective for a lot of people purely because it is related to a stimulant and produces refreshingly vigilant effects.
>
> If not Parnate, look into moclobemide for a decent serotonergic/noradrenergic/dopaminergic medication with a benign side-effect profile(http://www.dr-bob.org/tips/split/Experience-with-moclobemid.html)West,
Thanks for answering . I appreciated it.
I have to disagree on the antypsychotic issue though; I've been tried four types of AP so far, atypical ones included (levosulpiride) and they
made my depression worse. I've been searching for a scientific explanation for this and i found a research study which showed that a class of depressed people with dopamine related depression with severe drop in the dopamine firing neurons are not going to benefit from AP even at low doses.
Moreover, women are more susceptible to APs, since they increase prolactin, an hormone involved in the neuroendocrine pathway, whose disregulation can cause depression in a class of people.
I wanted to ask you a question about Moclobemide: is it a more potent dopamine reuptake inhibitor compared to venlafaxine?Thanks again
Anna Laura
poster:Anna Laura
thread:90578
URL: http://www.dr-bob.org/babble/20020116/msgs/90665.html