Posted by IsoM on January 17, 2002, at 1:22:34
In reply to Psychosis and Modafinil/Adrafinil » IsoM, posted by Raga on January 16, 2002, at 22:05:00
That's a nasty thing to have happen. No, I've never read anything like that with either. Doesn't mean it didn't or couldn't happen, just I never read it. I saw some poorly done images of the brain comparing the differences between what areas are activated with Ritalin/Dexedrine and with adrafinil/modafinil. The latter increases brain metabolism in a larger, more diffuse area than the regular stims. That may account for the psychosis from a Provigil overdose.
I've also read how methamphetamine (the original street speed) can lead to psychosis with continued use. It's related to Dexedrine but then it's used at much higher levels & more often. Some researchers believe that the psychosis is probably a pre-existing condition triggered by the stimulant.
The case you came across - did it say anything else? Did the person have mild psychosis before? Did he recover afterwards? And do you know how much Provigil he took?
The only thing I came across was a small part about one man attempting suicide on one or the other - Provigil or adrafinil, I forget which. He took 57 x the maximum dosage (where'd he get so much?) and after a couple of rough days was back to normal.
It's what I read & I'm reporting it exactly the same way, BUT whether this is accurate, I've no way of verifying. Unless the info comes with references or from very reliable sources, I don't necessarily trust what it says - but I do note it.
It's difficult to find much on adrafinil. It's not been particularily noticed in North America & most studies (what few there are) have been done in Europe. If you want to read anything on it, I can supply some links to different sites.
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> I got a question for you IsoM about Adrafinil and Provigil? In your investigation of it, did you hear anything about additional risk of either of them precipitating psychosis, such as paranoia or delusions?
>
> I came across 1 case where someone had a big psychotic break due to an -overdose- of Provigil. But I haven't seen anything about additional risk of psychosis on regular doses like we see with Ritalin or Dexedrine...
>
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> Anyone else can answer this too, or give me an idea of where to look or who to ask.
>
> Thanks a lot.
poster:IsoM
thread:90082
URL: http://www.dr-bob.org/babble/20020116/msgs/90577.html