Posted by Mitch on January 8, 2002, at 0:50:09
In reply to Re: S.S.R.I. tolerance and other stuff. » Mitch, posted by bob on January 7, 2002, at 23:58:38
> Mitch:
>
> Have you personally found Divalproex Sodium to have a robust antidepressant quality?Nope,
I have just heard others mention that *they* had an AD response at high doses-and relayed that information. I think they were BPI and needed the high dose Depakote to prevent mania and happened to discover an antidepressant effect at that dosage. The first time I tried it the only other mood stabilizer I ever was on was Lithium. I cross-tapered the lithium to Depakote and my depression got worse. No doubt about it. What Depakote did for me (with a BPII, ADHD dx)was help me sleep and reduced mixed-state anxiety. I still got grouchy on it (I call it "sullen"-that is the best description), but there wasn't any hypomania thrown in. I felt like picking fights with people-I just wasn't excited about it (a depressive sort of "if I can't kick your ass-you will kick mine-so what" kind of feeling/thinking). It affects GABA significantly and other "GABA-ergic" mood stabilizers (i.e.-Topamax) and diazepam could make me quite hostile, sullen, or indifferent. I attribute that to my ADHD (it tends to worsen it).
Mitch
poster:Mitch
thread:89256
URL: http://www.dr-bob.org/babble/20020103/msgs/89278.html