Posted by jimmygold70 on January 6, 2002, at 16:23:09
In reply to Re: Query: Serotonin syndrome...SSRI+MAOI interaction, posted by Triss on January 5, 2002, at 19:34:37
Sure, but the noradrenergic tricyclics are at least as effective. You're not 'tied' to serotonin-specific drugs ! Depression is not caused from lack of serotonin. rather, all monoamine-active drugs influence other, some known, some yet to be discovered chemicals in the brain (like desensitization of central alpha receptors). The effect of noradrenergic drugs is much more profound on depression than the serotonergic drugs, but they have more side effects and are activating rather than calming, like serotonergic drugs. Don't switch from fluvoxamine to maprotiline / prtriptyline / desipramine directly - take them together for two weeks, than taper fluvoxamine for another two weeks. After that, wait two weeks when you're only on maprotiline / prtriptyline / desipramine, and start taking Nardil along with them. While you take Nardil dose up, taper the noradrenergic drugs quickly.
Sure this will be a much smoother 'switch'.
Jimmy
poster:jimmygold70
thread:88818
URL: http://www.dr-bob.org/babble/20020103/msgs/89072.html