Posted by mdertinger on January 3, 2002, at 12:21:59
In reply to Re: What's the difference btwn remeron and serzone? » MM, posted by SalArmy4me on July 20, 2001, at 0:52:47
You forgot to mention that a side effect of Remeron is weight gain and increased appetite.
> Comparison to of Remeron to Serzone:
>
> 1. Remeron is more convienient than Serzone because its taken once at bedtime (Serzone is taken BID).
>
> 2. Remeron has the potential for increase of libido due to its blockade of the alpha-2 NE receptor, unlike Serzone.
>
> 3. Remeron might provide relief from Serzone's nausea due to the blockade of the 5HT-2C receptor.
>
> 4. Remeron can be started at a therapeutic dose, unlike Serzone which requires titration for toleration (http://www.preskorn.com/cgi-bin/sp.pl?words=doxepin&wt=be&bl=an&d=/books/omd_s8.html)
>
> 5. The risk of pharmacokinetically mediated drug-drug interactions is higher with Serzone due to the inhibition of the drug metabolizing CYP 3A3/4 enzyme; nefazodone has the potential to cause CYP enzyme-mediated drug-drug interactions like fluoxetine, fluvoxamine, and paroxetine. Nefazodone-induced inhibition of CYP 3A3/4 can elevate levels of coprescribed drugs dependent on this CYP enzyme for their oxidative metabolism and that, in turn, can cause untoward consequences: http://www.preskorn.com/columns/9803.html
>
> > I didn't take well to SSRI's, but serzone was the best out of the bad I guess. Would remeron be basically the same?
poster:mdertinger
thread:70998
URL: http://www.dr-bob.org/babble/20020103/msgs/88627.html