Posted by OldSchool on January 1, 2002, at 11:43:03
In reply to Re: Has anyone read, Your Drug May Be Your Problem » sjb, posted by Mitch on January 1, 2002, at 10:04:57
> As with nearly everything, there are politics and money involved. We probably are going to see a period of reduced polypharmacy in the next few years (for good or ill). I noticed that Lilly is going to market fluoxetine/olanzapine together in one pill for treatment resistant depression.
This is going to mess up a lot of people who are primarily mood disordered, IMO. While Zyprexa plus SSRI can work for many non psychotic treatment resistant depressives, Zyprexa brings with it all the risks of the development of movement disorders. Persons with unipolar major depression are at much higher risk of development of movement disorders than are persons with psychotic disorders.
I found even low dose Zyprexa numbed my tongue up and made my muscles stiff, just as low dose Risperdal did and low dose Seroquel did.
What is going to happen when Eli Lilly gets this Zyprexa/Prozac combo FDA approved for non psychotic TRD is you are going to see a rash of EPS and other movement disorders in individuals who really shouldnt be on anti-psychotics. Yes, I realize that the official pharmaceutical literature will tell you that the newer atypical anti-psychotics do not cause movement disorders at high rates, this is not necessarily true in individuals who are primarily mood disordered.
I am a perfect example of this. I was recently dxed with a nasty case of EPS from augmenting 50 mg Seroquel with an SSRI for slightly over a month. I have TRD unipolar major depression.
I predict a rash of movement disorders and subsequent lawsuits against Eli Lilly if Zyprexa plus Prozac is FDA approved for non psychotic TRD.
People with refractory mood disorders would be much better off and safer if they would just go back to basics and have old fashioned ECT rather than messing with all these weird psychopharmacology cocktails. ECT is actually safer than neuroleptics in individuals whose problem is a mood disorder.
Old School
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URL: http://www.dr-bob.org/babble/20011222/msgs/88423.html