Posted by adamie on December 26, 2001, at 23:12:27
In reply to If Anyone Wants To Learn About Adrafinil, posted by IsoM on December 26, 2001, at 13:59:42
when i was off meds i went on adrafinil. after a few days i felt a bit better. then the 3rd day i felt like a small miracle overcame me. i felt like i was able to live again. i was actually looking forward to the future. the drug was very stimulating. i would be thinking a lot. and it would make it extremely hard to sleep. like my mind would be always active. this severe lack of sleep maybe was what caused me to feel horrendously worse the 4th. a huge difference. i went from feeling extremely livable to feeling suicidal. maybe if i had a sleep aid then none of that would have happened. maybe adrafinil would have been a miracle for me. but it makes me wonder why i felt so much worse on the 4th day. and then it continued onto the 5th day. then i stopped the adrafinil and felt suicidal anyway. then i started a new combo and felt slightly better. at least not suicidal. maybe i should try adrafinil again in the future.> I'm always on the lookout for any information on adrafinil and/or modafinil & how they work. I came across this article on adrafinil from the CNS Drug Reviews. It was written by Norton W. Milgram, Heather Callahan, & Christina Siwak of the Division of Life Sciences, University of Toronto at Scarborough, Toronto, Ontario, Canada. It's very well written & is not difficult to understand. If it seems too long for anyone, you could just go to the Conclusions & Summary at the end & read that but you'll miss some good information.
>
> I found it very interesting how it hypothesised that adrafinil may have three possible modes of action - as a selective a1-adrenergic receptor agonist, by modifying the intracerebral release of amino acids (both GABA & glutamate), & by increasing cerebral metabolism in certain areas of the brain. Adrafinil is also metabolised into two different metabolites, one an amide & one an acid. One of the metabolites of adrafinil is modafinil itself!
>
> It also discussed 6 separate studies done on human volunteers in hospitals in France & the correlation betweeen similar effects among all 6 studies. I honestly think that both adrafinil & modafinil will prove to be very promising drugs due to their widespread effect on different neurotransmitters & their mode of action. I find it to be quite the wonder drug for me but people need to be aware that it doesn't have immediate effects for most, & if it does, it may be placebo-induced. Maximum effects occured around day 45 of treatment but continued to increase even afterwards.
>
> Here's the link to the article:
> http://www.nevapress.com/cnsdr/full/5/3/193.pdf
> (You'll need Adobe Acrobat to read this file.)
poster:adamie
thread:87881
URL: http://www.dr-bob.org/babble/20011222/msgs/87919.html