Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: CAM: SSRIs and Our Body's Synthesis of Serotonin

Posted by BobS. on December 20, 2001, at 19:18:28

In reply to Re: CAM: SSRIs and Our Body's Synthesis of Serotonin » IsoM, posted by Cam W. on December 20, 2001, at 15:35:47

Cam,
Are you saying that individuals who are "polymorphic for CYP-2D6" are more susceptable to SSRI withdrawal? If so, how does one determine if they harbor this genetic variation?
Thanks,
BobS.
> IsoM - I would think that SRIs would force our bodies to produce more serotonin. SRIs block the reuptake of serotonin back into the presynaptic neuron, so the body is unable the reuse the neurotransmitter. The serotonin "trapped" in the gap is, for the most part, metabolized, but the levels of serotonin in the gap are still going to be higher while taking the antidepressant than they would be after the antidepressant is stopped. This would result in the serotonergic withdrawl syndrome that is seen; and the less serotonin the body is producing would result in more severe withdrawl effects. This would be exacerbated in those people who also are polymorphic for CYP-2D6 (ie. have multiple copies of the cytochrome-P450-2D6 enzyme gene).
>
> This mechanism is different from adding levothyroxin (Synthroid™) in hypothyroidism, as you are not adding serotonin to the body with SRIs, you are blocking it's reuptake. The body is still responsible for producing all the serotonin that it is using.
>
> That's the way I see it, anyway. - Cam


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:BobS. thread:3670
URL: http://www.dr-bob.org/babble/20011213/msgs/87571.html