Posted by Darwin on December 16, 2001, at 15:15:01
In reply to Serzone: Does it even work?, posted by dhldn on December 16, 2001, at 11:14:55
Nefazadone worked for me, but only for about a month. During that month, it relieved my dysthymia better than any other antidepressant I had tried. After that month, I started developing severe mental fatigue and backache which eventually caused me to quit Nefazadone. I wonder if those metabolites you mentioned had anything to do with the negative side effects.
From anecdotal reports, I get the impression that Nefazadone does tend to "Poop Out" earlier and more often than most antidepressants. One rarely reads of long term success stories with Nefazadone.
Nefazadone does have an advantage over Trazadone in that it is a much weaker alpha-1 antagonist. Thus, related side effects such as priapism and orthostatic hypotension are less of a problem.
I would like to point out that re-uptake inhibition of serotonin or norepinephrene or dopamine is probably not a requirement for antidepressant efficacy. For example, the mysterious tricyclic antidepressant Trimipramine is not a re-uptake inhibitor yet is recognized as an effective antidepressant.
Darwin
poster:Darwin
thread:87093
URL: http://www.dr-bob.org/babble/20011213/msgs/87115.html