Posted by Elizabeth on December 13, 2001, at 20:24:00
In reply to Re: high-dose Effexor - anyone? » Elizabeth, posted by Cam W. on December 13, 2001, at 15:45:49
> Elizabeth - I wonder if one can use dosages to determine when the noradrenergic effects of Effexor would kick in.
I was thinking more of the dopaminergic effects. (Like I said, *high* doses, meaning 300+ mg/day.)
But I wonder -- I guess I assumed that at least some research had been done to this effect, but I never went and looked for it.
> We especially see differences in CYP-2D6 polymorphism.
Is CYP-2D6 involved in any of the metabolic pathways of Effexor? I'm particularly interested since there's good reason to believe that I have this polymorphism.
> I think that this factor might have something to do with the protracted withdrawl that some people experience (ie. those with naturally higher levels of CYP-2D6 metabolize the drug faster, thus setting themselves up for the withdrawl syndrome).
That might explain why I never experienced any kind of withdrawal from ADs other than MAOIs.
-elizabeth
poster:Elizabeth
thread:86308
URL: http://www.dr-bob.org/babble/20011213/msgs/86845.html