Posted by JohnX2 on December 11, 2001, at 12:32:19
In reply to Re: starting Topomax » jazzdog, posted by JohnX2 on December 11, 2001, at 12:26:31
Hi Jane,
I forgot to answer your weight loss question.
It doesn't seem to make me feel "full" or
"nauseaus" like stimulants or Wellbutrin.I just don't ever feel hungry. So I don't think
it is speeding up my metabalism. Why I don't
ever feel hungy is a mystery that the doctor's
can't explain. I still can enjoy food. And if
I eat too much, then my stomach does send me
a "full" signal.What were you referring too WRT to zoloft?
-John
>
> Jane,
>
> The only reason I can think that topomax is
> curing my myofacial pain is that one of its mode
> of anti-convulsant action is similiar to klonopin's
> mode on anti-convulsant action. I read this in an
> article which compared topamax to diazepam.
> Basically there are 2 types of Gaba neurons, GabaA
> and GabaB, an elelectrolyle chlorine is negatively
> charged and is passed through the neuron to inhibit
> the conductance of the receiver of the neuron.
> Both Klonopin and Topomax increase CL- (chlorine)
> conductance in the GabaA type neuron. Other meds
> like Depakote works on the GabaB type neuron.
> Other anti-convulsants try to prevent the break
> down of gaba instead of trying to enhance the working
> of gaba. I'd explain neurologically why I think
> stimulating GabaA neurons is good (as well as blocking
> serotonin 5ht-2a neurons or noradrenaline alpha-1
> neurons) but it is rather involved. The net
> result in my case is increased dopamine in
> an are of my brain where dopamine inhibits
> acetycholine stimulation of muscle contraction
> of jaw/head muscle contraction.
>
> At least that's MY theory,
> and my response to a wide variety
> of meds is consistent to it.
>
> meds that relieve my pain:
>
> anticholinergics: benadryl,chlorphenramine
> dopaminergic:Adderall,
> 5ht-2 antagonist:Zyprexa,Serzone
> GabaA:Klonopin,Topomax.
>
> Why I don't get the other side effect typical to
> anti-convulsants is a bit of a mystery. Usually
> the anti-convulsants make me stuporous,slurred speech, and give me
> blurry vision, Topomax just givems me the same
> side effects as Klonopin, which is a slight sedation.
> Topamax also modulates gluatamate at the AMPA
> receptors and Lamictal modulates gluatmate at
> the NMDA receptors. ITS POSSIBLE (just a hypothesis),
> that some sort of interaction with lamictal actually
> stabilizes the Topmax (kinda like a mood stabilizer,
> right...twilight zone...).
>
> Anyways, at the GabaA receptor I would only expect
> sides effects like the benzos, but at the AMPA I
> might expect side effects like the other
> anti-convulsants. Just my 10 cents.
>
> -john
>
>
>
>
>
> > Hi John -
> >
> > Topamax is pretty interesting to me, especially in conjunction with Lamictal and Zoloft. How does it manage to be both sedating and weight-loss promoting? I thought only activating drugs sped up the metabolism enough to cause weight loss. Also, are you experiencing any cognitive dulling? A lot of people seem to complain about it, and god knows my brain is already dulled enough. Good news about the facial pain - any theories why it's working?
> >
> > - Jane
poster:JohnX2
thread:86328
URL: http://www.dr-bob.org/babble/20011202/msgs/86570.html