Posted by JohnX2 on November 19, 2001, at 13:09:11
In reply to Re: amphetamine sensitization article, posted by Hattree on November 19, 2001, at 8:35:37
I've tried tyrosine supplement but generally
they only give a short lived response. The problem
is that tyrosine (the precursor to dopamine and
noradrenaline) is generally not the bottleneck
in producing those chemicals. The bottleneck
is something called tyrose hydroxylase, which
could be a target for anti-depressants in the
future.I think there is a good chance that meds will
come out that prevent "poop-out". At least
that is what I am experimenting with. A few
people on this group reported success with
memantine (available in germany, in phase III
clinical trials in the US) preventing
stimulant poop-out.-john
> I have been diagnosed as ADD inattentive type (distinctly not hyperactive), along with dysthymia.
> Stimulants help for both, but I too struggle with the poop out.
>
> I try to deal with it by switching back and forth between different stimulants and taking holidays (not easy--I have two little kids).
> Now that I take lamictal, I can go days without the poop out and don't get as much anxiety (also the dysthymia is much better), but stimulant management is still a constant issue. I just got some L-tyrosine to try. Any experience with that?
>
> And yes, I have had to increase the dose over time, but I'm a small doses person, so that only means I'm up to about 7.5 mg/day of dextrostat, taken all at once. I supplement with a cup of coffee in the late afternoon.
>
> >
> > The practical implicaition is to understand the
> > underlying mechanism so that we can treat
> > addiction, tolerance, and sensitization to the
> > medication (in this case amphetamine).
> >
> > Sorry, it is extremely technical, but it is an
> > area I have been researching greatly because I
> > have a medication poop-out problem; this cruel
> > trick where a stimulant or anti-depressant works
> > for a few hours and then stops. I believe that
> > understand the addiction pathway and how to
> > alleviate it will counterattack my cruel friend
> > mr. dysthymia.
> >
> > And yes ironically
> > if you need amphetamines for ADD then
> > probably the article is a tough read!
> >
> > Are you ADD or was that just a simple statement
> > that the article is a bit boring and complex?
> >
> > If you are ADD do you take stimulants? Do they
> > always work at the same dose over time?
> >
> > regards,
> > -john
> >
> >
> > > Looks interesting but I'm too attention deficited to read it--what is the practical implication?
> > > >
> > > > I thought this was an interesting article
> > > > discussing the means for development of amphetamine
> > > > sensitization/tolerance. Interesting conclusion
> > > > regarding serotonin being the culprit.
> > > >
> > > > http://www.ucsf.edu/cnba/Center/JournalClub/Articles/9780.pdf
poster:JohnX2
thread:84550
URL: http://www.dr-bob.org/babble/20011113/msgs/84663.html