Posted by JohnX2 on November 7, 2001, at 19:58:34
In reply to Re: Give up on Zyprexa? » JahL, posted by JohnX2 on November 7, 2001, at 19:54:44
Regarding the synergy. I think there is a
synergy between Lamictal and Zyprexa.
Lamictal stabilizes electrolytes to the nmda
receptors (stimulated by glutamate). Zyprexa
antagonizes the serotonin 5ht-2a receptors
which indirectly stimulate nmda receptors.-john
>
> Hi Jahl,
>
> I take 150 mg of Lamictal/day. I found this to be
> the minimum dose that eliminates all major
> depression symtoms and peripheral neuropathy. It doesn't cure my dysthymia
> however. It doesn't flatten my mood like the
> other anti-convulsants. I tried 225, which was
> about the same as 150. At 300 mg, lamictal
> does this weird thing that zoloft and wellbutrin
> do which is it gives me a bad tension headache
> and make me feel emotionally detached. It has a wierd dose response
> curve for me since between < 150 ineffective,
> between 150-225 helps all symptoms, > 225
> makes things worse. Strange. Doctor can't think
> of a reason why.
>
> After stumbling onto lamictal, i have been trying
> adjunctive meds to see if they would help with the
> dysthymia and tension headaches. 1st I tried the AD's I took that knocked
> out the depression and made me manic (Wellbutrin
> and Zoloft). Unfortunately they didn't work with
> lamictal. I also tried trileptal at my latest
> pdocs suggestion and I hated it. I then asked for
> zyprexa because of I believed a med that antagonized
> the 5ht-2 serotonin receptor would help with
> my chronic tension headaches and dysthymia. The
> only other med that did this was Serzone which
> made me too drowsy and drunk feeling (I crashed
> my car). Fortunately Zyprexa has helped remakedly
> with my anxiety/headaches and somewhat with the dysthymia
> (I take 5 mg/day). It doesn't affect my cognition
> like Serzone did. My boss even commented the other
> day that I was "looking better". Those dark rings
> under my eyes have disappeared and I've reclaimed
> my appetite.
>
> regards,
> -john
>
>
> > >
> > > If you tried anti-convulsants?
> > > When all else fails....lamictal.
> > > I don't think I can personally think of
> > > a single person who got more depressed on
> > > lamictal, so its worth a go. A lot of
> > > people have done well combining lamictal
> > > with zyprexa (me).
> >
> > Hi John.
> >
> > I agree Lamictal is unlikely to worsen depression.
> >
> > Can I ask what doses of Lamictal & Zyprexa you take? Which did you start first? Do you feel their relationship to be synergistic or are the effects just additive? Any other info along these lines?
> >
> > Thanks,
> > J.
poster:JohnX2
thread:83395
URL: http://www.dr-bob.org/babble/20011104/msgs/83472.html