Posted by JahL on November 6, 2001, at 21:22:13
In reply to Re: Opinions on drug combo please, posted by SLS on November 6, 2001, at 13:43:31
> Did you find trimipramine sedating or soporific?Soporific. It's probably telling that Trimip. was first prescribed to me as a sleep aid (classic lifetime depressive; saw my GP for everything *but* depression 'cause I knew no different). It was about as effective (at 50mg/hs) as any legal med I've taken for this purpose.
When we got round to dealing with the depression itself we raised the dose, with 200mg the target. During the day it wasn't particularly sedating (the soporific effects would wear off overnight); in fact if I remember rightly, I was pretty wired/agitated throughout the day. The problem was staying awake after dosing (soln: take at bed-time,) and waking up (alarm clock *not* a soln.). Above 100mg & I would sleep like a baby for 15/16 hours at a time. I like my sleep but that's overdoing it...
I had a similar problem with Dothiepin, another AD beloved of UK pdocs, again because of its sedative 'qualities' (& cheapness).
>After being on it for a while, did you feel sedated or fatigued during the day. I'm interested in trimipramine, but I'm afraid that it will be too sedating. I'm real sensitive to that.
So am I. My brain is slow enough; it needs no help in that direction. My guess is that you might have problems with it, but YMMV & all that. My brother (soft bipolar) tried it recently & gave up after a couple of days. Said it left him 'down a hole'. I think I know that feeling.
> Also, did you gain weight on it?
No, but then I'm not a good measure. It goes against all my instincts to have an appetite. It never occurs to me to eat so I have to force myself. If anything it reduced my appetite. All that agitation y'see.
In terms of A-C side-effects I found it similar to Dothiepin and preferable to Imipramine, Nortriptylene & Chloripramine (in that order). Generally pretty tolerable.
It was some time ago, but I think I remember my depersonalisation worsened considerably.
Er, that's about it,
J.PS That Biploar URL you posted the other day was pretty good. Ta. Feel free to post anything along similar lines...
poster:JahL
thread:83247
URL: http://www.dr-bob.org/babble/20011104/msgs/83393.html