Posted by SLS on November 6, 2001, at 13:37:34
In reply to Re: synaptic/neuro plasticity?, posted by JGalt on November 6, 2001, at 8:54:27
> Interesting stuff. I'd wondered what it was before but hadn't looked it up yet... I did some research on it after reading this thread, but only managed to confirm what Cam said rather than finding much to add on to it. Its good to have this information, as it backs up the information I had (both online and personally) about GHB interfering with memory when using it a few consecutive days to go to sleep (since GHB makes your body prefer Stage 4 sleep to dream state).
I guess this all relates to memantine and dextromethorphan?What's interesting about memantine is that although it is generally thought to reduce neuroadaptive changes (reduce plasticity), it actually can enhance memory and learning. It is known to improve cognition, especially in dementia. This is sometimes thought of as being paradoxical, but it really isn't. Perhaps memantine is selective as to what, when, and where it inhibits synaptic changes. Since "forgetting" is the result of a plastic event, reducing plasticity would allow memories to persist. Something might be learned "deeper" in that once made, fewer connections are lost during the consolidation process (LPT?).
Just a few plastic thoughts...
- Scott
poster:SLS
thread:83236
URL: http://www.dr-bob.org/babble/20011104/msgs/83347.html