Posted by SLS on November 6, 2001, at 10:46:59
In reply to Re: Gepirone and Atypical Depression » SLS, posted by pat c. on November 4, 2001, at 14:19:34
> One of the top doctors at NY Psychiatric (don't want to name him) told me that the first trial showed that people with atypical depression had 40% positive response to Gepirone.
>
> It blew his mind, and he has been doing this for decades.
>
> He said that Bristol Meyers Squibb was crazy for selling it to Organon.
>
> Now they're doing another trial, I guess for Organon.
>
> Pat
>
Hi Pat.Thanks for the information.
I would be interested to speak to some people up at Columbia myself. I know some of the doctors up there, including Fred Quitkin.
If you wouldn't mind, I would be grateful for you to correspond with me directly for further discussions.
For me, it is probably very unfortunate that gepirone and the other azapirones are extensively metabolized in the body to 1-PP, a potent NE alpha-2 receptor antagonist. Of course, this is probably a good thing for the vast majority of people. Idazoxan and mirtazepine, both alpha-2 antagonists, make my depression substantially worse. I'm worried that my taking gepirone will lead to a similar exacerbation.
http://www.acnp.org/g4/GN401000109/CH107.html
"An additional mechanism that might contribute is the metabolism of the azapirones to 1-(2-pyramidal)-piperazine (1-PP), which achieves brain concentrations tenfold higher than the parent component (13); 1-PP is an a2-adrenergic antagonist, a drug class that has been hypothesized to have antidepressant properties (see below). In one clinical study, 1-PP plasma levels were significantly correlated with improvement in depressive symptoms in patients treated with buspirone (79)."
Take care.
- Scott
poster:SLS
thread:80214
URL: http://www.dr-bob.org/babble/20011104/msgs/83327.html