Posted by SLS on November 4, 2001, at 12:28:16
In reply to dopamine receptor supersensitivy, posted by JohnX2 on November 1, 2001, at 3:41:12
Hi John (and others)
> Looking for info on dopamine receptor
> supersensitivy articles/background.
> Experts out there?Not me.
> Have read interesting theories on how
> psychostimulants can cause dysfunctional
> pre/post synaptic dopamine receptor ratios,
> sensitivity,feeback inhibition.
> I also believe this could be a source of med-poop out.
> Also believe that it can be reversed
> (possibly using an NMDA antagonist
> + a dopamine agonist/antagonist). Just a hunch...
>
> -john
Check-out ibogaine:http://www.med.nyu.edu/Psych/ibogaineconf/objectives.html
It is a NMDA receptor antagonist that has quite a bit of history involving use for the treatment of drug addiction. It seems to prevent or reverse neuroadaptive changes (eg. receptor sensitivity) resulting from drug exposure. It also does a bunch of other things that I'm sure you'll have fun researching.
- Scott
poster:SLS
thread:82845
URL: http://www.dr-bob.org/babble/20011104/msgs/83175.html