Posted by SLS on November 1, 2001, at 18:04:36
Hi Medlib.
Redirected from:
http://www.dr-bob.org/babble/social/20011025/msgs/13010.html
I don't know if there is some official way to re-direct things so...
> I'm also trying to understand how d/cing the Geodon led to "false suffocation syndrome"/panic attacks.
I had a few thoughts.
The role that Geodon plays as a 5-HT1a agonist might account for this. It differs from all other neuroleptics in this regard. If two weeks of treatment with Geodon causes a downregulation of 5-HT1a autoreceptors, its discontinuation might yield an increase in the excitability of anxiogenic serotonergic pathways.
> (I'm having mini-versions of the same thing tapering off Mirapex. It's bound to be a dopamine-mediated response, but what kind? Mirapex has no 5HT action at all.) My main reason for trying to unravel all this is to ascertain if there is something I can take w. Geodon which will ameliorate the EPSE while retaining its mood/energy benefits. So far, Geodon has been the only med that really "worked" (as opposed to "helped") for me.
Have you ever used buspirone as an augmenting agent? Perhaps 5-HT1a receptor stimulation would be helpful for you.
If you are looking for an antidepressant neuroleptic devoid of 5-HT2 antagonism, you might want to investigate sulpiride (Dogmatil, Sulpirex). It is a very inexpensive drug that is available in many countries. Dosages of 50mg - 100mg are considered therapeutic.
I hope you come up with a way to deal with the oro-facial stuff. Won't an anticholinergic help?
- Scott
poster:SLS
thread:82909
URL: http://www.dr-bob.org/babble/20011025/msgs/82909.html