Re: Thanks Sunnely!

Posted by SLS on October 31, 2001, at 7:31:34

In reply to Re: Thanks Sunnely! » Daveman, posted by JohnX2 on October 31, 2001, at 4:49:52

Hi John.
> Eli-Lilly tried this with Prozac (weeding out the inactive isomer in hopes to reduce side effects), but if my memory serves me correct it didn't help much.
Lilly stated that they discontinued r-fluoxetine because of treatment-emergent cardiovascular side effects (prolongation of QT interval) at the highest dosage tested. They really shot themselves in the foot here. They tested the r-enantiomer at dosages equivilant to the racemate, even though 1/2 that amount would have been biologically equivilant. Lilly decided not to invest the time and money to conduct the trials at lower dosages that would be required for FDA approval. The program would be delayed by two years.

- Scott

Thread

Any new AD's in the making? steve2 10/23/01
Re: Any new AD's in the making? » steve2 Mitch 10/24/01
Re: Any new AD's in the making? (Mitch) steve2 10/24/01
What's new about the new Celexa? daveman 10/25/01
Re: What's new about the new Celexa? » daveman Sunnely 10/26/01
Thanks Sunnely! Daveman 10/29/01
Re: Thanks Sunnely! » Daveman JohnX2 10/31/01
Re: Thanks Sunnely! SLS 10/31/01

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