Posted by JGalt on October 29, 2001, at 10:04:38
In reply to Re: PROVIGIL POOPOUT: 2 YEARS, STRONGER THAN EVER, posted by Rick on October 29, 2001, at 0:53:10
Interesting on the enzyme bit. It would seem to follow that using Klonopin+Provigil would also prolong the effects of each, at least until the body managed to produce enough extra enzyme to counteract both, if it does so in this case.
> It makes sense that Provigil should do a great job countering Serzone-induced fatigue since Serzone is a powerful inhibitor of one of Provigil’s primary metabolization enzymes, P450 CYP3A4. I.e. Serzone increases blood concentrations of Provigil and prolongs its wakefulness effects (no problems sleeping when I WANT to, though). It’s a great combo, especially given Provigil’s motivational and confidence-building properties (I have non-depressive Social Phobia). Klonopin is also believed to be metabolized largely via CYP3A4, so its anti-anxiety effect is prolonged by Serzone as well. This all allows me to take lower doses of everything – all of it first thing in the morning.
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> Rick
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poster:JGalt
thread:81227
URL: http://www.dr-bob.org/babble/20011025/msgs/82561.html